7-Hydroxymitragynine is a natural alkaloid present in the kratom plant (Mitragyna speciosa) native to Southeast Asia. It is found in low concentrations in raw kratom leaves but constitutes the major compound that contributes to the potency and psychoactive effects of the plant. As kratom has become popular as a stimulant and pain reliever, 7-hydroxymitragynine and hydroxy-mitragynine are attracting increasing attention among researchers and health enthusiasts, including regulators.
Let us take this moment to explore the effects of 7-hydroxymitragynine, how it differs from 7 hydroxymitragynine benefits ,side effects, and whether it is safe to be used regularly.
What is 7-Hydroxymitragynine?
7-Hydroxymitragynine is a tertiary alkaloid derived from mitragynine, the most abundant active compound in kratom. 7-hydroxymitraqynine is unique in the sense that it is highly potent towards opioid receptors, mainly mu-opioid receptors. Studies have proposed that 7-hydroxymitragynine could be ten to twenty times more potent than morphine if compared molecule-to-molecule, though studies have agreed that its quantity in kratom is relatively low in comparison.
Most 7-hydroxymitragynine in the body is not present in the raw form in the kratom leaf; rather, it is formed when mitragynine is metabolized in the liver. The metabolization helps increase the pain-relieving and sedative attributes of kratom.
7-Hydroxymitragynine Effects
Some key effects of 7-hydroxymitragynine are:
1. Intense Pain Relief
Because of this compound’s strongest affinity to mu-opioid receptors, it effectively relieves pain. It is commonly being used among kratom consumers for chronic pain, arthritis, injury, or postoperative pain.
2. Mood Enhancement
Users often report feelings of exhilaration, calm, and mental clarity when consuming kratom strains with a high concentration of Hydroxymitragynine effects. It may also staple anxiety and depression symptomatology due to its tranquilizing and mood-enhancing profile.
3. Sedation and Relaxation
At larger levels of dose, the 7-hydroxymitragynine may make a person sedated-would be a good choice for evening use or assistance with sleep. This effect works well for someone with insomnia or restlessness.
4. Mild Euphoria and Well-Being
The euphoria stimulated by 7-hydroxymitragynine is milder yet cleaner than that of synthetic opioids and thus they impart a certain feeling of well-being without extreme highs or lows.
Hydroxymitragynine Effects: Comparative Study
The term 7-hydroxymitragynine effects sometimes refers to all kratom-related compounds bearing the hydroxyl group, including 7-hydroxymitragynine. It might also be applied to chemically altered or semi-synthetic forms of mitragynine derivatives.
In General, Hydroxymitragynine Effectings Are Softer:
- Pain relief
- Mood stabilization
- Calmness and concentration
- Modulation of opioid receptors
The major difference is the potency: Hydroxymitragynine effects is very potent, much more so than mitragynine or any other hydroxylated compounds, and is therefore believed to be the major factor in kratom’s opioid-like effects.
Side Effects of 7-Hydroxymitragynine
That being said, it does have side effects associated with it. Major side effects include:
- Nausea and vomiting
- Dizziness or vertigo
- Constipation
- Dry mouth
- Drowsiness
- Loss of appetite
After higher doses, more serious side effects may come to life:
- Respiratory depression
- Dependence and withdrawal symptoms
- Tolerogenic buildup
- Cognitive fogginess
High-dose use or prolonged use could lead to actual physical dependence, because of its activity at opioid receptors. On the other hand, kratom is thought to be less addictive than the classic opioids.
Is 7-Hydroxymitragynine Safe?
The question “Is 7-hydroxymitragynine safe?” cannot be answered with a simple yes or no. When taken responsibly with moderate dosages and within the limits of individual tolerance, it may be relatively safe-well, far safer than pharmaceutical opioids.
Factors affecting safety:
- Amount: Acceptable amounts are classified as low to moderate doses.
- Frequency: Use every day builds tolerance and dependence.
- Form: Concentrated kratom extracts can have very high levels of 7-hydroxymitragynine, so the risk is increased.
- Polydrug use: Combining kratom with other depressants (alcohol, benzodiazepines) can be fatal.
Kratom is not approved by the FDA for medical use at the present time, and research is ongoing. On the upside, an increasing number of anecdotal and clinical reports suggest kratom, in conjunction with 7-hydroxymitragynine, could play a significant harm-reduction role in assisting those coming off stronger opioids.
Hence, in general, 7-hydroxymitragynine is safe in measured doses but caution should be exercised when dealing with extracts or chronic consumption.
